Endocrinology

Trilostane, LH assay, canine hypothyroidism and Cushing’s syndrome

  • Using trilostane at a low dose

    It seems that several dogs can be clinically stabilised at doses around the lower values of the recommended doses (2.2 – 6.7 mg/kg/J) whereas cortisol values after ACTH stimulation are higher than the reference values recommended in the instruction leaflet (1.95 – 5.12 microg/dL).

  • LH test and ovarian remnant syndrome

    The LH (Luteinizing Hormone) test is available at the laboratory to detect ovarian remnant syndrome in female dogs and cats. It can be used to detect if there is any remaining ovarian tissue remains or to distinguish between sterilised and un-sterilised females.

  • Therapeutic monitoring for canine hypothyroidism

    Therapeutic monitoring can be done within 2 weeks of the beginning of the treatment or when the dose is adapted. Many practitioners use the total T4 test to judge the efficacy of the treatment.

  • Evaluation of 2 protocols using trilostane to treat Cushing’s syndrome in dogs (PDH Pituitary Dependent Hyperadrenocorticism)

    A study performed at the University of Madrid compared the efficacy of administering Trilostane twice a day versus once a day, as well as the safety index of both protocols in the treatment of PDH in dogs.

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